Prototyping Neural Networks Learn Lyme Borreliosis Stefano Rovetta *, Rodolfo Zunino *, Laura Buffrini **, Guido Rovetta ** University of Genova, Italy * Faculty of Engineering, DIBE ** Faculty of Medicine, DIMI ABSTRACT In this paper, the application of neural network algorithms to the study of Lyme borreliosis is addressed. Three different methods are studied: Self Organizing Maps, Neural Gas Networks and a new approach currently under development, called Circular Back Propagation. The aim of the work is to compare the three methods in view of their use as analysis tools, to ex-plore the inherent structure of the input data. The same procedure has been previously applied to feedforward neural models; the present work focuses on a particular form of knowledge representation, based on a set of proto-typal examples rather than if-then rules. The Lyme data has been chosen as a case study and represents a common ground to allow the comparison of the different methods. SUBJECT TERMS medical computing; self-organising feature maps; backpropagation; knowledge representation; neural networks; Lyme borreliosis; self organizing maps; neural gas networks; circular backpropagation; analysis tools; feedforward neural models; knowledge representation; medical application ----- Proceedings of the 8th IEEE Symposium on Computer-Based Medical Systems Lubbock, Texas, USA, June 1995, pp. 111-117. Copyright (c) 1995 Institute of Electrical and Electronics Engineers, Inc. All rights reserved.