Research Theme: Community
detection in biomolecular networks
PhD Program in Bioengineering and Robotics
Tutors: Francesco Masulli,Stefano Rovetta, Giuseppe Russo
Department: DIBRIS (University of Genova)
http://www.dibris.unige.it
Description: Inferring groups of interacting
proteins or genes with biologically significance is a main trend
of the current bioinformatics research, as this task can help in
revealing the functionality and the relevance of specific
macromolecular assemblies or even in discovering possible
macromolecules affecting a specific biological process. Protein
and gene interaction networks can be modeled similarly to social
interaction networks, so that these biologically significant
groups correspond to communities. Reliable algorithms able to
discover such communities may increase knowledge about
biological functions at a molecular level, and may support drug
discovery and enhance disease treatments even in earlier stages.
This project is aimed at the development of effective tools for
community detection in biological networks using methods of
network and graph theories, machine learning, and computational
intelligence. For instance, a significant application goal,
important for cancer biomarker research, is a better
understanding of the role of miRNAs, a novel class of non-coding
RNA able to modulate the expression of their target genes. The
available algorithms, mostly based on structural information,
are still not able to provide a biological enrichment of their
results, that can instead be obtained from the
proposed analysis.